Deletion of <i>S100a8</i> and <i>S100a9</i> Enhances Skin Hyperplasia and Promotes the Th17 Response in Imiquimod-Induced Psoriasis

Abstract High concentrations of the damage-associated molecular patterns S100A8 and S100A9 are found in skin serum from patients suffering psoriasis, an IL-17–related disease. Notably, although expression these proteins correlates with psoriatic disease severity, exact function psoriasis pathogenesis remains unclear. In this study, we investigated role psoriasis-associated hyperplasia immune responses using S100a8?/? S100a9?/? mice imiquimod-induced model psoriasis. We that exhibit worsened clinical symptoms relative to wild-type increased keratinocytes, respectively. addition, loss enhances proliferation keratinocytes disrupts keratinocyte differentiation. further detected elevated production IL-17A -F CD4+ T cells absence S100A9, as well infiltration neutrophils skin. treatment anti–IL-17A was reduce mice. These data suggest regulate by inhibiting -F, thereby, our knowledge, providing new insights into their biological functions.